FIG 5.

Genetic-association analysis at the human locus syntenic with murine Chr 3 with the age at the first P. aeruginosa infection. Color coding indicates the linkage disequilibrium (r²) between rs10875080 and the other SNPs analyzed in the region. Association analysis was conducted for the square-root-transformed age at the first P. aeruginosa infection (in 712 individuals with CF) with 17,139 SNPs at the human locus (chromosome 1 Mb 97.0 to 105.0; human genome version 19) syntenic with the murine QTL that is associated survival in the presence of P. aeruginosa infection.