TABLE 1.

P. aeruginosa modifier candidate genes ranked with the Beegle online tool^a

Rank	Gene	Protein
1	S1pr1	Sphingosine-1-phosphate receptor 1
2	Vcam1	Vascular cell adhesion protein 1
3	Col11a1	Collagen alpha-1(XI) chain
4	Dpyd	Dihydropyrimidine dehydrogenase (NADP+)
5	Agl	Amylo-1,6-glucosidase,4-alpha-glucanotransferase
6	Cdc14a	Dual-specificity protein phosphatase CDC14A
7	Snx7	Sorting nexin 7
8	Ptbp2	Polypyrimidine tract-binding protein 2
9	Lrrc39	Leucine-rich-repeat-containing protein 39
10	SLC30A7	Solute carrier family 30 (zinc transporter), member 7
11	Palmd	Palmdelphin
12	Dbt	Dihydrolipoamide branched-chain transacylase
13	Gpr88	G-protein-coupled receptor 88
14	Dph5	Diphthine methyl ester synthase
15	Frrs1	Ferric-chelate reductase 1

^aThe ranking among the final 15 candidate disease modifier genes was generated by the Beegle informatics tool (http://beegle.esat.kuleuven.be/). Beegle software started by mining the literature to quickly extract a set of genes known to be linked with the query “lung infection” and then train a genomic model and rank the set of the 15 candidate genes within the murine QTL.