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. 2020 Mar 10;11(2):e00176-20. doi: 10.1128/mBio.00176-20

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Copyright © 2020 Martinez et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Immunogenetic characteristics of Env-specific IgG MAbs isolated from HIV-infected U.S. and Malawian women. (A and B) V_H gene usage of Env-specific IgG MAbs isolated from nontransmitting and transmitting women. (C) V_H somatic hypermutation frequency of HIV Env-specific IgG MAbs isolated from nontransmitting (blue) (NT) and transmitting (red) (T) women. n.s., differences were not statistically significant. (D) V_H somatic hypermutation frequency of gp120, V1V2, V3, and CD4 binding site-specific IgG MAbs. V_H somatic hypermutation frequencies were statistically significantly different across different epitope specificities (ANOVA P = 0.014). (E) HCDR3 amino acid length of Env-specific IgG MAbs. The P value in panel D compares the V_H somatic hypermutation frequency of V1V2 to those of V3, the CD4 binding site, and gp120-specific IgG MAbs in both nontransmitting and transmitting women.