FIG 5.

Maternal N332 glycan-targeting memory B cells and infant-T/F virus V3 glycan genetic signatures in mother-infant pair 9105. (A) N332 V3 glycan-specific peripheral blood memory B cells as defined by CD19⁺ IgD^– and CD38 all are shown by the red gate. (B) OD binding of N332 glycan-targeting monoclonal antibody H691380 isolated from woman 9105 against the Man₉-V3 peptide. The dashed lined denotes the positivity cutoff. (C) V3 loop amino acid residues in woman 9105 nontransmitted maternal Env variants and infant-T/F virus 9112. Maternal Env amplicons from transmitting women are shown in the red font, and the infant-T/F virus is in the black font.