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. 2020 Mar 3;11(2):e03046-19. doi: 10.1128/mBio.03046-19

FIG 1.

FIG 1

The pilin-linked disaccharide and biosynthetic pathway. Strain MS11 pilin glycosylation and pilin-linked glycan structures. (a) Pilin-linked glycan biosynthesis begins at the gonococcal cytoplasmic membrane. The pilin glycosyltransferase, PglA, transfers a galactose to a lipid-linked basal sugar, diNAcBac. The Gal(α1-3)diNAcBac lipid structure is “flipped” to the periplasm by PglF and then attached to the structural pilus subunit, PilE (at Ser63), by PglL. (b) The Gal(α1-3)diNAcBac disaccharide structure expressed on MS11 pilin when the phase-variable gene pglA expression is on.