Table 4.

Potential differential metabolites in the depression group in comparison with the control group.

	Number	Metabolite	HMDB ID	KEGG ID	RT (min)	m/z	Similarity	VIP	p value	Trend
ESI+	1	Dihydrothymine	HMDB0000079	C00906	115.58	129.06	0.741	2.31	0.017	↓∗
	2	Cortisone	HMDB0002802	C00762	280.76	361.20	0.711	2.21	0.022	↓∗
	3	Indole-3-carbinol	HMDB0005785	—	213.40	147.04	0.686	2.49	0.004	↓∗∗
	4	4-Ethylbenzoic acid	HMDB0002097	—	248.36	151.07	0.537	1.84	0.038	↓∗
	5	3-Methyluridine	HMDB0004813	—	55.189	259.09	0.638	1.77	0.044	↑∗
ESI−	1	Formylanthranilic acid	HMDB0004089	C05653	145.02	164.03	0.974	1.98	0.007	↓∗∗
	2	Glycoursodeoxycholic acid	HMDB0000708	—	271.957	448.31	0.937	1.88	0.038	↓∗
	3	3-Hydroxyhippuric acid	HMDB0006116	—	133.45	194.05	0.898	2.33	0.013	↓∗
	4	m-Cresol	HMDB0002048	C01467	68.77	107.05	0.828	2.38	0.011	↑∗
	5	Hydroxyphenyllactic acid	HMDB0000755	C03672	69.68	181.05	0.808	2.01	0.012	↓∗
	6	Azelaic acid	HMDB0000784	C08261	109.58	187.09	0.778	1.822	0.031	↓∗
	7	Vanillin	HMDB0012308	C00755	68.72	151.04	0.768	2.47	0.010	↑∗
	8	Dimethylglycine	HMDB0000092	C01026	32.81	102.06	0.726	2.93	0.012	↑∗
	9	Gentisic acid	HMDB0000152	C00628	76.71	153.02	0.718	1.99	0.049	↓∗
	10	17a-Ethynylestradiol	HMDB0001926	C07534	229.01	295.17	0.539	1.33	0.049	↓∗

Note: vs. control group—^∗p < 0.05 and ^∗∗p < 0.01.