Figure 1.

Apoptotic exosome‐like vesicles (ApoExo) are novel triggers of IL‐17 production and tertiary lymphoid structure (TLS) formation in vascular allografts. Mice were injected with the vehicle (n = 13) or ApoExo (n = 16) for 3 weeks posttransplantation: (A) Aortic allograft sections stained with H&E, CD20, CD3, AID, and IL‐17 (magnification: 5×; magnification of right inset panels: 20×). (B) Ratio intima/media in the allografts. (C) Mean number of TLS per allograft. Neointima‐media and perivascular quantification of CD20⁺ B cells (D), CD3⁺ T cells (E), AID (F), and IL‐17 (G) staining in each high‐power field of the allografts. Data were pooled from 3 independent experiments and expressed as means ± SEM. Comparison with the vehicle was done with a Student's t test