Figure 1.

Circulating CCR9 + Th cells have enhanced CXCR3, CCR4 and CCR6 expression and pSS patients show decreased proportions of CCR9 + Th cells expressing CXCR3 and CCR6. Representative flow cytometry images (A) and combined data of multiple healthy donors (n = 5‐11; B) showing increased expression of CXCR3, CCR4 and CCR6, but not CCR10 on circulating CCR9+ vs CCR9− Th cells. Mean with SEM are shown. C, In primary Sjögren's syndrome (pSS) patients circulating CCR9+ central memory, effector memory and effector Th cells expressing CXCR3 and effector memory cells expressing CCR6 are significantly decreased. In addition, circulating CCR9+ effector memory Th cells from pSS patients show elevated percentages of CCR4‐expressing cells. Medians are shown unless specified otherwise, healthy controls (HC): circles, pSS patients: triangles, pSS n = 11‐17, HC n = 5‐11, *P < .05, **P < .01, ***P < .001