Figure 9.

Mitochondrial respiration in ZSF1‐lean and ZSF1‐obese animals. Maximal NADH‐linked respiration with glutamate, malate and pyruvate (A), oxidative phosphorylation (OXPHOS) capacity with additional succinate‐driven respiration (B), and maximal uncoupled electron transport capacity (C) all tended to be significantly lower (0.05 < P < .10) in ZSF1‐obese compared to ZSF1‐lean animals. D, Succinate‐driven (complex II) respiration was not different between groups. E‐F, Normalized respiration by complex I substrates tended to be lower, while normalized complex II respiration was higher, suggestive of mitochondrial complex I dysfunction in ZSF1‐obese compared to ZSF1‐lean animals