Figure 7.

Schematic summary of proposed signaling mechanisms for Piezo1‐dependent ATP release from hDP‐MSC and regulation of cell migration. Activation of the Piezo1 channel induces ATP release. ATP activates the P2 receptors and induces activation of the proline‐rich tyrosine kinase 2 (PYK2) and the mitogen‐activated protein kinase/extracellular signal‐regulated kinase (MEK/ERK), which may act as upstream and downstream signaling pathways (as depicted here) or independent signaling pathways, leading to an increase in cell migration. The activators and inhibitors used in this study to target various signaling molecules are highlighted in green and red, respectively