Table 3.
(a) COPD top (b) Asthma top ten differentially expressed genes between individuals with high (>200 eosinophils/μL) and low blood eosinophil counts, ranked by expression fold change
| Gene symbol | Gene expression fold change | P value | P value FDR corrected |
|---|---|---|---|
| (a) | |||
| TTTY15 | 3.68 | 1.5E‐04 | .26 |
| NLGN4Y | 3.48 | 1.3E‐04 | .26 |
| CLCA1 | 2.98 | 1.0E‐05 | .14 |
| PSMA6P1 | 2.80 | 1.8E‐04 | .26 |
| TBL1Y | 2.77 | 1.8E‐04 | .26 |
| FETUB | 2.69 | 1.0E‐05 | .14 |
| IL9R | 2.22 | 1.5E‐04 | .26 |
| CLC | 2.19 | 1.8E‐04 | .26 |
| GPRC5D | 1.51 | 9.0E‐05 | .26 |
| SH3RF2 | 1.20 | 1.7E‐04 | .26 |
| (b) | |||
| S100A8 | 2.5 | 2.6E‐04 | 3.5E‐02 |
| SRGN | 2.3 | 5.2E‐04 | 4.4E‐02 |
| IGK///IGKC | 2.2 | 1.7E‐04 | 3.4E‐02 |
| TPSB2 | 2.2 | 1.8E‐04 | 3.5E‐02 |
| MNDA | 2.1 | 4.7E‐04 | 4.2E‐02 |
| ALOX5AP | 2.1 | 2.3E‐04 | 3.5E‐02 |
| TPSAB1 | 2.1 | 1.7E‐04 | 3.4E‐02 |
| LCP1 | 2.1 | 3.3E‐04 | 3.7E‐02 |
| SLC25A37 | 2.0 | 7.9E‐04 | 4.7E‐02 |
| RGS2 | 2.0 | 2.4E‐05 | 2.1E‐02 |
Abbreviations: ALOX5AP, arachidonate 5‐lipoxygenase‐activating protein; CLC, Charcot‐Leyden crystal galectin; CLCA1, calcium‐activated chloride channel protein 1; FETUB, fetuin‐B; GPRC5D, G‐protein‐coupled receptor family C group 5 member D; IGK, immunoglobulin kappa locus; IL9R, interleukin‐9 receptor; LCP1, lymphocyte cytosolic protein 1; MNDA, myeloid cell nuclear differentiation antigen; NLGN4Y, neuroligin 4, Y‐Linked; PSMA6P1, proteasome subunit alpha 6 pseudogene 1; RGS2, regulator of G‐protein signalling; S100A8, S100 calcium‐binding protein A8; SH3RF2, SH3 domain containing ring finger 2; SLC25A337, solute carrier family 25 member 37; SRGN, serglycin; TBL1Y, transducin‐beta‐like protein 1; TBSB2, tryptase beta 2; TPSAB1, tryptase alpha/beta 1; TTTY15, testis‐specific transcript, Y‐linked 15.