Table 1.

Literature estimates of aspiration risk during procedural sedation^a

Study	Population	Principal Agent	Endoscopy?	Total Subjects	Aspiration overall	Aspiration during non‐fasted procedures	Aspiration mortality
Bhatt 39	Children	Ketamine	No	6295	None	None	None
Beach 19	Children	Propofol	Some	139,142	1:13,914	1:12,701	None
Chiaretti 40	Children	Propofol	Some	36,516	None	None	None
Friedrich 41	Adults	Propofol	All	15,690	1:541	Not stated	None
Rajasekaran 42	Children	Propofol	All	12,447	None	None	None
Agostoni 43	Mixed	Propofol	All	17,999	1:1,000	Not stated	None
Dean 44	Mostly adults	Propofol	None	62,125	None	Not stated	None
Green 45	Children	Ketamine	None	8282	None	None	None
Rex 46	Adults	Propofol	All	646,080	Not stated	Not stated	None
Horiuchi 47	Adults	Propofol	All	10,662	None	None	None
Vespasiano 48	Children	Propofol	None	7304	1:7,304	Not stated	None
Onody 49	Mostly Children	Nitrous oxide	Some	35,828	None	None	None
Tohda 50	Adults	Propofol	All	27,500	1:6,875	Not stated	None
Sanborn 51	Children	Pentobarbital	None	16,467	1:8,234	None stated	None
Walker 52	Adults	Propofol	All	9152	1:9,152	Not stated	None
Gall 53	Children	Nitrous oxide	Some	7511	None	None	None

^aTo include just the largest studies, we display those with 5000 or more patients. We also exclude studies which report duplicate subsets of patients.