Table 3.

Other myeloid‐related genes more frequent in AML, MPN and other MDS/MPN.

Gene	Region Frequent mutations	Type of mutation	Frequency
			MDS (%)	CMML (%)
Frequent in myeloproliferative neoplasms
CALR	Exon 9 Codons: all	Frameshift	<1	<1
CBL	Exons 8 and 9 Codons: 366–420	Missense	<5	8–18
CSF3R	Complete coding region Hotspot codons: 618	Missense	<1	3–4
GATA2	Exons 2 and 6 Codons: all	Missense, frameshift	<5	<1
MPL	Complete coding region Codons 505 and 515	Missense	<1	<1
NF1	Complete coding region Codons: all	Nonsense, frameshift, splicing	<5	<5
PTPN11	Exons 3 and 7 Codons: all	Missense	<1	4
Frequent in acute myeloid leukaemia
BCOR	Complete coding region Codon: all	All	<5	<5
BCORL1	Complete coding region Codons: all	Nonsense, frameshift	<1	<1
CEBPA	Complete coding region Codons: all	Missense, frameshift	<5	<5
ETV6	Complete coding region Codons: all	Nonsense, frameshift	<5	<1
FLT3	Exons 13–15 and 20 Hotspot codons: FLT3‐ITD and D835	Missense, frameshift	<5	<5
KIT	Exons 2, 8–11, 13 and 17 Codons: all	Missense, frameshift	<3	<1
NPM1	Exon 11 Hotspot codons: W288	Frameshift	<5	<5
WT1	Exons 7 and 9 Codons: all	Missense, frameshift	<3	<3

CMML, chronic myelomonocytic leukaemia; ITD, internal tandem duplication; MDS, myelodysplastic syndrome.