Table 4.

Characteristics of CHIP, ICUS, CCUS and MDS.

	CHIP	ICUS	CCUS	MDS
Cytopenia	No	Yes (≥1)	Yes (≥1)	Yes (≥1)
Dysplasia	No	No, or minimum	No, or minimum	Yes
Mutations	Yes (n = 1)	No	Yes (n ~ 1, 6)	Yes >85% (n ~ 2, 6)
VAF	2–12%	–	30–40%	30–50%
Progression Risk	0.5–1% per year	>10% in 5 years	>85% in 5 years

CCUS, clonal cytopenia of uncertain significance; CHIP, clonal haematopoiesis of uncertain significance; ICUS, idiopathic cytopenia of uncertain significance; MDS, myelodysplastic syndrome; VAF, variant allele frequency.