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. 2020 Jan 16;250(3):346–357. doi: 10.1002/path.5376

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© 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Demonstration of TET2 mutations and CD4 positivity in two clonal T‐cell populations of AITL030. (A) Double BaseScope in situ hybridization shows the presence of both TET2 mutations in the two clonal T‐cell populations of AITL030. Please note that the BaseScope probes were designed to hybridize to mRNA, thus yielding stronger signals for highly expressed (TRB) than lowly expressed (TET2) genes. (B) Double BaseScope ISH and immunohistochemistry demonstrate that both clonal T‐cell populations are CD4 positive, but CD8 negative.