Fig. 8.
Confocal Ca imaging in 27-week-old animals after 1 h incubation with CM-NSF and CM-SF from 21-week-old animals. Transversal line scans at 1 Hz steady state stimulation. TF50, time-to-peak, Ca peak, and tau of decay of WT (A-D), HHD (E-H) and HFpEF (I-L). Myocardial tissue levels of ET-1 in the left atrium at 27 weeks (M). Correlation of LA ejection fraction and myocardial ET-1 (N). Myocardial tissue levels of ET-1 in a cohort of patients (O). The control group is represented by patients with a BMI ≤ 25 and no history of AHT.