Table 2.

Optum Research Database: Effects of triglycerides on cardiovascular (CV) events and medical resource utilization in statin‐treated patients with elevated atherosclerotic CV disease risk (multivariate analysis)^{a , b}

	Hazard or cost ratio for cohort variable (95% CI)		P	Hazard or cost ratio for cohort variable (95% CI)		P
	TG ≥1.69 mmol/L vs comparatora			TG 2.26–5.64 mmol/L vs comparatora
Initial major CV eventc	1.26	(1.19–1.34)	<0.001	1.35	(1.23–1.49)	<0.001
Non‐fatal MIc	1.32	(1.2–1.45)	<0.001	1.35	(1.19–1.52)	<0.001
Non‐fatal strokec	1.14	(1.04–1.24)	0.004	1.27	(1.14–1.42)	<0.001
Coronary revascularizationc	1.46	(1.33–1.61)	<0.001	1.51	(1.34–1.69)	<0.001
Unstable anginac	1.18	(0.71–1.96)	0.527	1.21	(0.65–2.26)	0.555
CV‐related deathc , d	1.17	(0.90–1.52)	0.125	1.33	(0.97–1.83)	0.076
Total healthcare costse	1.12	(1.08–1.16)	<0.001	1.15	(1.08–1.21)	<0.001
Initial inpatient hospital stayc	1.13	(1.10–1.17)	<0.001	1.17	(1.11–1.22)	<0.001

Abbreviations: CI, confidence interval; CV, cardiovascular; MI, myocardial infarction; TG, triglycerides.

Adapted with permission from Toth et al.44, 45

^aOverall pre‐match cohort: TG ≥1.69 mmol/L (n = 25 452 patients); comparator pre‐match cohort: TG <1.69 mmol/L and HDL cholesterol >1.04 mmol/L (n = 31 805 patients); pre‐match subcohort: TG 2.26–5.64 mmol/L (n = 13 411 patients); comparator pre‐match cohort: TG <1.69 mmol/L and HDL cholesterol >1.04 mmol/L (n = 32 506 patients).

^bSeparate pre‐match multivariate analyses of major CV events, total healthcare costs and initial inpatient stay were performed. Covariates included TG cohort, as represented here, along with age (45–54, 55–64, ≥65 years), sex, insurance coverage type, geographic region of enrolment, baseline clinical characteristics (diabetes, ASCVD, LDL cholesterol laboratory result in relation to median), and baseline medication use (fibrates, prescription omega‐3s, both, and neither).

^cMultivariate analysis using Cox proportional hazards model.

^dEvent occurred in an inpatient setting with discharge status indicating a non‐fatal event (absence of CV‐related death; CV‐related death was defined as death in the follow‐up period [as identified with discharge status or the Death Master File]) based on diagnosis code for major CV events (MI, stroke, revascularization) in the first or second position, that occurred in an emergency department setting within 1 day of a death date, or in an inpatient stay with a discharge date within 7 days of a death date.

^eGeneralized linear model (gamma distribution, log link).