Table 3.
Percentage of cases and controls in 10‐year breast cancer risk groups defined using classical factors (Tyrer–Cuzick (TC) model), mammographic density (D) and SNP143
| Ten‐year risk group (%) | ||||||
|---|---|---|---|---|---|---|
| Risk algorithm | Sample | <1.4% | 1.4–3.5% | 3.5–5% | 5–8% | 8%+ |
| TC | Control | 20 (1.2%) | 1,153 (69.1%) | 285 (17.1%) | 173 (10.4%) | 37 (2.2%) |
| TC × D | Control | 141 (8.5%) | 977 (58.6%) | 281 (16.8%) | 186 (11.2%) | 83 (5.0%) |
| TC × SNP143 | Control | 293 (17.6%) | 862 (51.7%) | 247 (14.8%) | 182 (10.9%) | 84 (5.0%) |
| TC × SNP143 × D | Control | 372 (22.3%) | 804 (48.2%) | 194 (11.6%) | 175 (10.5%) | 123 (7.4%) |
| TC | Case | 5 (1.2%) | 261 (64.4%) | 68 (16.8%) | 54 (13.3%) | 17 (4.2%) |
| TC × D | Case | 19 (4.7%) | 194 (47.9%) | 98 (24.2%) | 60 (14.8%) | 34 (8.4%) |
| TC × SNP143 | Case | 25 (6.2%) | 171 (42.2%) | 84 (20.7%) | 79 (19.5%) | 46 (11.4%) |
| TC × SNP143 × D | Case | 38 (9.4%) | 134 (33.1%) | 79 (19.5%) | 95 (23.5%) | 59 (14.6%) |