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. 2019 Dec 22;250(3):262–274. doi: 10.1002/path.5367

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© 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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PATH-5367-FIG-0003-c — Using real‐time measurements to understand axillary lymph node (ALN) biology. (A) Cancer‐replaced ALNs (n = 3) showed a higher flow rate during perfusion than cancer‐free ALNs (n = 5) over time (two‐way ANOVA; p < 0.0001; mean with SD). (B) Cancer‐replaced ALN with pan‐cytokeratin‐positive cancer cells filling the subcapsular sinus (scale bars: 50 μm). (C) Heatmap of the five significantly differentially expressed genes between cancer‐free and cancer‐replaced (metastatic) perfused ALNs (|log₂ FC| > 1 and q < 0.1; blue, down‐regulated; red, up‐regulated). (D) Concentration of CXCL12 and CXCL11 in the perfusate of cancer‐free and cancer‐replaced ALNs measured using an ELISA assay (n = 10, performed in triplicate).