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. 2020 Jan 13;250(3):299–311. doi: 10.1002/path.5374

Figure 2.

PATH-5374-FIG-0002-c

Overexpression of Cisd2 alleviates neuronal loss and inflammation in female AD mice. (A) (B) IF staining for NeuN (red) reveals a reduced number of neurons in the granule cell layer (A) and hilus (B) of the dentate gyrus (DG) in the hippocampus of AD mice. (C) IF staining for Iba1, a microglia marker, in the hippocampus of the WT, AD, Cisd2TG, and AD;Cisd2TG mice. (D) Density quantification of Iba1+ cells obtained from three sections per mouse and three mice for each group. All mice were 12‐months‐old. Mean ± SD. *p < 0.05, **p < 0.005.