Table 2.

In Vivo experiments studying the potential of ADSCs when coinjected in fat grafts and the effects of ADSCs on breast cancer

Reference	Study model	Regeneration Strategy	Cells	Benefits	Risks	Therapy for
(Jiang et al., 2015)	Mice	Fat graft enriched with ADSCs and enriched with ADSCs+bFGF	ADSCs from human lipoaspirates and bFGF	Weight of the graft ↑ Survival ratio for graft↑	None	Breast augmentation
(Tsuji et al., 2018)	Mice	Fat graft enriched with ADSCs	ADSCs from human lipoaspirates MDA‐MB‐231, BT‐474 breast cancer cells	Tumor growth↓ Angiogenesis ↑	None	Breast augmentation after mastectomy
(Rowan et al., 2014)	Mice	Fat graft enriched with ADSCs	ADSCs from human lipoaspirates MDA‐MB‐231 breast cancer cells	Tumor growth ↔ if BMI = 25.0	Tumor growth ↔ if BMI=18.3	Breast augmentation after mastectomy
(Orecchioni et al., 2013)	Mice	Fat graft enriched with ADSCs	ADSCs from human lipoaspirates HCC1937, MDA‐MB‐436, ZR75‐1 breast cancer cells	None	Tumor growth ↑Metastatic spread ↑EMT ↑	Breast augmentation after mastectomy
(Martin‐Padura et al., 2012)	Mice	Fat graft enriched with ADSCs	Murine whole fat HMT‐3522 S3 (preinvasive), HMT‐3522 T4‐2 (invasive) MDA‐MB‐231 breast cancer cells	Angiogenesis ↑	Tumor growth ↑Metastatic Spread ↑	Breast augmentation after mastectomy
(Zimmerlin et al., 2011)	Mice	Fat graft enriched with ADSCs	Human abdominal whole fat Human MPE breast cancer cells	None	Tumor growth↑ (active cells, but not resting cells)	Breast augmentation after mastectomy
(Sun et al., 2009)	Mice	Fat graft enriched with ADSCs	Human breast whole fat MDA‐MB‐231 breast cancer cells	Tumor growth↓ Metastatic spread↓ No early carcinogenesis improvement	None	Breast augmentation after mastectomy

Abbreviations: ADSCs, adipose‐derived stem cells; BMI, body mass index; bFGF, basic fibroblast growth factor.