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. 2020 Jan 28;72(3):477–487. doi: 10.1002/art.41100

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© 2019 The Authors. Arthritis & Rheumatology published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Vascular response to vasoconstrictor and vasodilator agents. A, Contractile response to KCl in pulmonary arterial rings obtained from female mice >18 months of age. Symbols represent individual mice; bars show the mean ± SEM. B and C, Vasodilating response to acetylcholine (Ach) (B) and sodium nitroprusside (SNP) (C) in pulmonary arterial rings obtained from female mice >18 months of age. Values are the mean ± SEM. * = P < 0.05; ** = P < 0.01, by Student's 2‐tailed t‐test (A) and by two‐way analysis of variance (B). AEP = active effective pressure (see Figure 1 for other definitions).