Figure 3.

Procoagulant activity of plasma extracellular vesicles (EVs) in platelet‐depleted plasma prepared from patients treated with ticagrelor and clopidogrel determined as the concentration of phosphatidylserine‐exposing EVs (A) and as the ability of EVs to generate fibrin in platelet‐free, but EV‐containing plasma following recalcification (fibrin generation test) in absence and presence of antibody against human tissue factor (activated factor VII; B‐D). A, includes EVs exceeding the side scatter threshold (≥10 nm²), having a diameter >200 nm, having a refractive index <1.42, and being positive for the labelled fluorophore. CT, clotting time; OD, optical density