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. 2020 Jan 29;250(3):323–335. doi: 10.1002/path.5372

Figure 1.

PATH-5372-FIG-0001-c

Mutational features of EC with POLE variants in the TCGA. The colour scheme for the mutation type is on the right of the histogram. Cases are grouped by mutations, with the most frequent POLE mutations in first place. The COSMIC 10 signature contribution, the points obtained in the POLE pathogenicity score (POLE‐score), the recurrence of the variant in EC, microsatellite instability (MSI) status, and POLE domain mutated are colour‐coded (legend on the right of the histogram). Below are the cases without POLE mutations; two rows depict the median plus standard deviation of the base change proportions and tumour mutation burden (TMB) of MSI‐H and MSS ECs without a POLE mutation in the TCGA.