Figure 3.

POLEmut–p53abn EC IHC and molecular features. Subclonal p53 staining and H&E stain of a POLEmut–p53abn EC are shown in A (×5 original magnification). Percentage of cases with subclonal and diffuse abnormal p53 staining patterns is depicted in B. (C) Heatmap showing hierarchical clustering of POLEmut–p53abn, single‐classifier POLEmut, and single‐classifier p53abn ECs in TCGA, based on mutational changes and copy number changes. Individual similarity metrics for copy number and mutational changes were combined using Euclidean distance. Patients were classified in groups based on POLEmut–p53abn (pink), single‐classifier POLEmut (blue), and single‐classifier p53abn (red). Samples were ordered based on hierarchical clustering.