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. 2019 Oct 29;38(3):653–662. doi: 10.1002/jor.24491

Figure 2.

Figure 2

Dose‐dependent effect of insulin‐like growth factor‐1 (IGF1), IGF2, C‐type natriuretic peptide (CNP), bone metamorphic protein 7 (BMP7), and sprifermin on chondrocytes in monolayer. Two monolayer cultures were performed; one with IGF1, IGF2, and CNP and a second one with BMP7 and sprifermin. Relative expression of (A) col1a2, (B) col2a1, and (C) acan after 7 days of stimulation with increasing concentrations of growth factors. Data represent the mean ± standard error of the mean (SEM). *p < 0.05 versus control (culture medium only).