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. 2020 Feb 11;98(3):229–241. doi: 10.1111/imcb.12316

Figure 2.

Figure 2

Dimethyl itaconate (DI) treatment inhibited the production of cytokines in infected corneas. Compared with phosphate‐buffered saline (PBS) treatment, DI treatment markedly decreased the relative messenger RNA (mRNA) levels of (a) interleukin‐1β (IL‐1β) and (b) chemokine (C–X–C motif) ligand 1 (CXCL1) in corneas (n = 5) infected with Aspergillus fumigatus at 3 days postinfection (p.i.). (c–f) Western blot analysis showed that compared with PBS treatment, DI treatment reduced the protein expression levels of IL‐1β p17 and CXCL1 in corneas (n = 5) at 3 days p.i. N indicates normal corneas without any treatment. The experiments were repeated two times to ensure reproducibility. P‐values are presented as the mean ± s.e.m. *P < 0.05, ***P < 0.001. A.f, Aspergillus fumigatus; N, normal corneas; ns, no significance.