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. 2020 Feb 11;98(3):229–241. doi: 10.1111/imcb.12316

Figure 3.

Figure 3

Dimethyl itaconate (DI) inhibited the production of cytokines in infected human corneal epithelial cells (HCECs). Compared with phosphate‐buffered saline (PBS) treatment, DI treatment notably decreased the relative messenger RNA (mRNA) levels of (a) interleukin‐1β (IL‐1β), (c) IL‐8 and (e) IL‐6 at 8 h postinfection (p.i.). ELISA results showed that compared with PBS treatment, DI treatment suppressed the relative protein levels of (b) IL‐1β, (d) IL‐8 and (f) IL‐6 at 24 h p.i. in HCECs (n = 6). The experiments were repeated two times to ensure reproducibility. P‐values are presented as the mean ± s.e.m. ***P < 0.001. A.f, Aspergillus fumigatus; N, normal HCECs; ns, no significance.