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. Author manuscript; available in PMC: 2020 Jul 8.
Published in final edited form as: Sci Transl Med. 2020 Jan 8;12(525):eaay7205. doi: 10.1126/scitranslmed.aay7205

Fig. 6. SAHA mediates mitochondrial metabolism via post-translational modifications.

Fig. 6.

Assessment of (A) Acetyl-CoA concentrations and (B-F) protein acetylation patterns measured using mass spectrometry of LV samples from sham and sham+SAHA animals. Acetylation patterns on (B) histone 3, proteins of the (C) electron transport chain (ETC), proteins of the (D) malate-aspartate shuttle, proteins of the (E) TCA cycle, and proteins involved in (F) mitochondrial fatty acid oxidation. Data shown are means ± SEM. Statistical significance was determined by two-tailed Student’s t test with subsequent multiple testing correction by permutation-based FDR method (P < 0.05). NS, not significant. The number of animals included in each parameter is reported in table S7.