Table 1.
A summary of studies reporting sector analysis of peripapillary RNFL changes in schizophrenia, bipolar disorder and major depression. Effect size has been calculated as mean percentage reduction in disease versus healthy controls.
| Schizophrenia |
OCT type | Global | Superior |
Temporal | Inferior |
Nasal | ||
|---|---|---|---|---|---|---|---|---|
| Study | ST | SN | IT | IN | ||||
| Ascaso80 | TD | 7.8% | 6.3% | 7.9% | 9.4% | 10.7% | ||
| Ascaso75 | SD | 9.8%b | 10.7%b | 5.8% | 9.2% | 15.5%b | ||
| Celik72 | SD | 4.8% | 5.1% | 2.3% | 4.7% | 10.1% | 6.7% | 4.9% |
| Chu82a | TD | 1.0% | 0.9% | 0.9% | −0.8% | −0.1% | ||
| Lee62 | SD | 8.9% | 11.7% | 9.9% | 7.4% | |||
| Topcu-Yilmaz79 | SD | 0.0% | 0.8% | −2.2% | 1.4% | 2.3% | −1.4% | −1.2% |
| Yilmaz81 | SD | 5.9% | 1.7% | 3.5% | 3.8% | 7.9% | ||
| Bipolar disorder |
OCT type | Global | Superior |
Temporal | Inferior |
Nasal | ||
| Study | ST | SN | IT | IN | ||||
| Mehraban83 | SD | 6.8% | 4.8% | −1.3% | 8.0% | 10.5% | ||
| Kalenderoglu84 | SD | 5.9% | 3.9% | 5.3% | −0.1% | 3.5% | 7.8% | 3.1% |
| Khalil85 | SD | 14.8% | 11.3% | 7.4% | 9.3% | 3.6% | ||
| Polo86 | SS | 8.1% | 16.5% | 11.2% | 4.3% | 9.4% | 4.7% | 4.9% |
| Major depression |
OCT type | Global | Superior |
Temporal | Inferior |
Nasal | ||
| Study | ST | SN | IT | IN | ||||
| Yildiz87 | SD | −0.1% | 0.1% | 4.2% | –0.4% | −5.4% | ||
| Sönmez88a | SD | 1.7% | 1.2% | −0.9% | 0.2% | −0.1% | 2.6% | 4.6% |
Grey shading indicates statistical significance as chosen by each study investigator.
a
Mean of right and left eyes.
b
OD significant only.
IN, inferonasal; IT, inferotemporal; OCT, optical coherence tomography; RNFL, retinal nerve fibre layer; SD, spectral domain, SN, superonasal; ST, superotemporal; TD, time domain.