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Baseline frequencies of CD8+PD-1+ lymphocytes (a) and CD8+PD-1+CD73+ lymphocytes (b) in patients groups based on clinical benefit to nivolumab treatment. Baseline frequencies of CD8+PD-1+CD73+ lymphocytes in 1st line treatment (c) and 2nd/3rd line treatment (d) patients subgroups based on clinical benefit to nivolumab therapy. CB clinical benefit, n = 39/100; NCB no-clinical benefit, n = 61/100. Statistical analysis was performed with Mann–Whitney test. Line indicates the median
