Table 2.
The main autoantibodies in receptor autoimmune diseases and their pathogenic actions
| Autoantibody | Acronym | Subclasses | Action |
|---|---|---|---|
| TSH receptor antibodies | TRAb | IgG |
Stimulating TSH receptor Blocking TSH receptor Apoptosis of thyrocyte |
| Acetylcholine receptor antibodies | ACHRAb | IgG 1, IgG 3 |
Disruption of receptor signaling Complement-dependent internalization of receptor |
| N-methyl-d-aspartate receptor antibodies | NMDARAb | IgG, IgA, IgM | Crosslinking and internalization of receptor |
| Phospholipase 2 receptor antibodies | PLAR2Ab | IgG | Thickening of capillary wall |