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Mean and standard error of relative deltas of AMA (a–c) and liver biochemical markers (d–f) at successive time points in BN/AMA-positive individuals and in PBC patients. Relative delta: difference between any time point station and baseline value divided by baseline value. BN/AMA-positive biochemically normal AMA-positive individuals (blue solid line), PBC primary biliary cholangitis (red dashed line). *p < 0.05; ** < 0.01; ***p < 0.001
