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YY-1 expression is increased in the airways in asthmatic subjects. Endobronchial biopsy specimens were obtained from healthy and asthmatic subjects and analyzed by using immunohistochemistry for expression of YY-1+ and CD3+ cells (see the Methods section). A and B show representative staining of YY-1 and CD3, respectively, from a subject with asthma. C shows the mean ± SEMs of 6 healthy and 12 asthmatic subjects, respectively.
