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Partial YY-1 deficiency inhibits T-cell proliferation. Proliferation of spleen CD4+ T cells from WT and heterozygous (HET) mice was analyzed by monitoring CFSE dilution by means of immunofluorescence and flow cytometry. A shows representative data from 1 experiment, and B is the average ± SEMs of 3 experiments using antigen-stimulated TCR transgenic T cells from WT (red) and yy-1+/− (HET; blue) mice studied after 72 hours. *P < .05.
