Table 1.

Groups of RccHan:WIST rats for IV and IM administration of different doses of K1-70™

Group	Dose route	Dose level (mg/kg/dose)	Number of animals
			Subgroup 1
			Toxicity		Treatment free
			Male	Female	Male	Female
1	IV	0 (control)	10	10	5	5
2	IV	15 (low)	10	10	–	–
3	IV	50 (intermediate)	10	10	–	–
4	IV	150 (high)	10	10	5	5
5	IM	2 mg per dose (low)	10	10	5	5

			Subgroup 2
			Toxicokinetics
			Male	Female
1	IV	0 (control)	3	3
2	IV	15 (low)	9	9
3	IV	50 (intermediate)	9	9
4	IV	150 (high)	9	9
5	IM	2 mg per dose (low)	9	9

			Subgroup 3
			Hormone
			Male	Female
1	IV	0 (control)	5	5
2	IV	15 (low)	5	5
3	IV	50 (intermediate)	5	5
4	IV	150 (high)	5	5
5	IM	2 mg per dose (low)	5	5

IV intravenous infusion; IM intramuscular injection