. 2019 Nov 7;10(1):11. doi: 10.1186/s13317-019-0121-9

Table 3.

Thyroid hormone levels in the study rats on day 7 post IV and IM administration of different doses of K1-70™

K1-70™ dose	Sex	TSH (μIU/mL)	T3 (nmol/L)	T4 (nmol/L)
K1-70™ dose	Sex	Mean ± SD	Mean ± SD	Mean ± SD
Control	M	0.60 ± 0.36	0.74 ± 0.12	78 ± 15.2
Control	F	0.49 ± 0.16	0.75 ± 0.20	56 ± 14.5
15 mg/kg/dose (IV)	M	15.62 ± 3.37	< 0.46^a	< 26^a
15 mg/kg/dose (IV)	F	18.30 ± 4.86	< 0.46^a	< 26^a
50 mg/kg/dose (IV)	M	16.82 ± 3.70	< 0.46^a	< 26^a
50 mg/kg/dose (IV)	F	18.24 ± 3.19	< 0.46^a	< 26^a
150 mg/kg/dose (IV)	M	15.32 ± 2.23	< 0.46^a	< 26^a
150 mg/kg/dose (IV)	F	16.20 ± 2.95	< 0.46^a	< 26^a
2 mg/dose (IM)	M	17.46 ± 4.93	< 0.46^a	< 26^a
2 mg/dose (IM)	F	13.90 ± 3.08	< 0.46^a	< 26^a

Mean is of n = 5 animals per group per sex. One out of 10 rats injected IM with 2 mg doses of K1-70™ showed normal control levels of thyroid hormones 0.22 μIU/mL, 0.46 nmol/L and 61 nmol/L for TSH, T3 and T4 respectively and was not included in the range values. Total T3 levels in the serum were measured using the Siemens Centaur immunoassay system, and Total T4 and TSH levels were measured using Siemens Immulite system

M male, F female

^aThe concentration is below the detection limit