Table 8.
Thyroid hormone levels in male and female monkeys post IM administration of different doses of K1-70™
| Day | K1-70™ dose (mg/dose) | Sex | TSH (µlU/mL) | T3 (nmol/L) | T4 (nmol/L) |
|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | Mean ± SD | |||
| Predose | 5 | M | 0.58 ± 0.20 | 2.45 ± 0.37 | 53.8 ± 12.2 |
| F | 0.95 ± 0.56 | 2.75 ± 0.36 | 62.7 ± 11.8 | ||
| Day 7 | 5 | M | 20.08 ± 9.30 | 0.96 ± 0.20 | 27.4 ± 8.6 |
| F | 23.03 ± 10.44 | 0.84 ± 0.28 | 22.5 ± 3.3 | ||
| Day 22 | 5 | M | 78.69 ± 35.66 | 1.18 ± 0.45 | 28.2 ± 13.2 |
| F | 103.97 ± 26.90 | 1.21 ± 0.61 | 24.4 ± 4.9 |
Mean is of n = 5 animals per group per sex
Levels of thyroid hormones in serum, TSH, Total T3 and Total T4 were measured using Siemens Centaur immunoassay system
M male, F female, T3 triiodothyronine, T4 thyroxine, TSH thyroid stimulating hormone