Table 9.

Toxicokinetic parameters of K1-70™ in male and female monkeys following IV administration of different doses of K1-70™

Day	K1-70™ dose (mg/kg/dose)	Sex	Cmax (µg/mL)	tmax (h)	AUC(0–t) (µg h/mL)
1	10	M	275	0.6	27,000
		F	348	0.6	28,900
	30	M	1090	0.6	97,500
		F	1000	0.6	93,800
	100	M	2820	0.6	254,000
		F	3180	0.6	268,000
22	10	M	688	0.6	64,100
		F	597	8.5	66,900
	30	M	1910	0.6	195,000
		F	1710	8.5	173,000
	100	M	5610	0.6	595,000
		F	5560	0.6	592,000

The level of K1-70™ in serum was measured using the PK ELISA from RSR Ltd

AUC_(0–t) area under the concentration–time curve over the interval 0 to t, where t is the time of the last measurable concentration, C_max maximum serum concentration, F female, M male, t 168 h, t_max time to maximum serum concentration