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. Author manuscript; available in PMC: 2020 Aug 21.
Published in final edited form as: Annu Rev Nutr. 2019 May 31;39:75–94. doi: 10.1146/annurev-nutr-082018-124242

Figure 3.

Figure 3

Three-dimensional (3D) enteroids: sophisticated model systems for investigating intestinal epithelium. (a) Schematic of an enteroid. Small crypt-like projections decorate the surface of the enteroid. The apical cell surface faces the lumen, analogous to the morphology of the digestive tract. Panel a adapted with permission from Reference 84. (b) Bright-field image of a single, live differentiated mouse enteroid in culture. (c) 3D projection of a single differentiated mouse enteroid with the apical membranes stained for F-actin demonstrates apical–inward polarity.