Table 3.
Association between clinicopathological and genetic ancestry components by AIM-INDEL panel (n = 934).
| Variable/Categories | AFR | EUR | ASN | AME | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low n (%) | Int. n (%) | High n (%) | p-value | Low n (%) | Int. n (%) | High n (%) | p-value | Low n (%) | Int. n (%) | High n (%) | p-value | Low n (%) | Int. n (%) | High n (%) | p-value | |
| GENDER | ||||||||||||||||
| Male | 189 (54.5) | 153 (55.2) | 149 (48.1) | 0.149 | 155 (49.1) | 174 (55.2) | 162 (53.5) | 0.277 | 234 (52.6) | 114 (55.6) | 143 (50.4) | 0.517 | 212 (52.5) | 123 (53.2) | 156 (52.2) | 0.969 |
| Female | 158 (45.5) | 124 (44.8) | 161 (51.9) | 161 (50.9) | 141 (44.8) | 141 (46.5) | 211 (47.4) | 91 (44.4) | 141 (49.6) | 192 (47.5) | 108 (46.8) | 143 (47.8) | ||||
| AGE AT DIAGNOSE (IN YEARS) | ||||||||||||||||
| <50 | 74 (21.4) | 87 (31.4) | 96 (31.0) | 0.013 | 99 (31.3) | 82 (26.0) | 76 (25.1) | 0.453 | 115 (25.8) | 59 (28.8) | 83 (29.2) | 0.528 | 118 (29.2) | 59 (25.6) | 80 (26.8) | 0.701 |
| ≥50 to <75 | 225 (64.8) | 164 (59.2) | 185 (59.7) | 185 (58.5) | 198 (62.9) | 191 (63.1) | 275 (61.8) | 129 (62.9) | 170 (59.9) | 240 (59.4) | 150 (64.9) | 184 (61.5) | ||||
| ≥75 | 48 (13.8) | 26 (9.4) | 29 (9.3) | 32 (10.2) | 35 (11.1) | 36 (11.8) | 55 (12.4) | 17 (8.3) | 31 (10.9) | 46 (11.4) | 22 (9.5) | 35 (11.7) | ||||
| BRAZILIAN REGION OF ORIGIN | ||||||||||||||||
| South/Southeast | 308 (88.8) | 226 (81.6) | 232 (74.8) | <0.001 | 237 (75.0) | 262 (83.2) | 267 (88.1) | <0.001 | 369 (82.9) | 163 (79.5) | 234 (82.4) | 0.160 | 346 (85.6) | 187 (81.0) | 233 (78.0) | 0.052 |
| Midwest | 25 (7.2) | 32 (11.6) | 28 (9.1) | 32 (10.1) | 27 (8.6) | 26 (8.5) | 42 (9.5) | 15 (7.3) | 28 (9.9) | 34 (8.5) | 21 (9.0) | 30 (10.0) | ||||
| North/Northeast | 14 (4.0) | 19 (6.8) | 50 (16.1) | 47 (14.9) | 26 (8.3) | 10 (3.3) | 34 (7.6) | 27 (13.2) | 22 (7.7) | 24 (5.9) | 23 (10.0) | 36 (12.0) | ||||
| PRIMARY TUMOR SITE | ||||||||||||||||
| Right colon | 76 (22.0) | 77 (27.8) | 84 (27.1) | 0.331 | 77 (24.4) | 88 (27.9) | 72 (23.8) | 0.178 | 119 (26.7) | 49 (24.0) | 69 (24.3) | 0.417 | 103 (25.6) | 62 (26.8) | 72 (24.1) | 0.335 |
| Left colon | 171 (49.4) | 125 (45.1) | 133 (42.9) | 136 (43.0) | 140 (44.5) | 153 (50.7) | 211 (47.5) | 95 (46.6) | 123 (43.3) | 197 (48.8) | 102 (44.2) | 130 (43.5) | ||||
| Rectum | 99 (28.6) | 75 (27.1) | 93 (30.0) | 103 (32.6) | 87 (27.6) | 77 (25.5) | 115 (25.8) | 60 (29.4) | 92 (32.4) | 103 (25.6) | 67 (29.0) | 97 (32.4) | ||||
| CLINICAL STAGE (AJCC) | ||||||||||||||||
| 0/I | 47 (13.6) | 37 (13.4) | 36 (11.6) | 0.580 | 36 (11.4) | 42 (13.4) | 42 (13.8) | 0.833 | 60 (13.5) | 27 (13.2) | 33 (11.7) | 0.540 | 51 (12.7) | 29 (12.6) | 40 (13.4) | 0.877 |
| II | 129 (37.3) | 112 (40.6) | 114 (36.8) | 118 (37.3) | 122 (38.9) | 115 (38.1) | 172 (38.7) | 74 (36.1) | 109 (38.5) | 157 (39.0) | 89 (38.5) | 109 (36.6) | ||||
| III | 108 (31.2) | 92 (33.3) | 106 (34.2) | 114 (36.1) | 97 (30.9) | 95 (31.5) | 150 (33.8) | 62 (30.2) | 94 (33.2) | 136 (33.7) | 70 (30.3) | 100 (33.6) | ||||
| IV | 62 (17.9) | 35 (12.7) | 54 (17.4) | 48 (15.2) | 53 (16.8) | 50 (16.6) | 62 (14.0) | 42 (20.5) | 47 (16.6) | 59 (14.6) | 43 (18.6) | 49 (16.4) | ||||
| HISTOLOGICAL TYPE | ||||||||||||||||
| Adenocarcinoma | 325 (93.6) | 261 (94.2) | 285 (91.9) | 0.429 | 294 (93.0) | 286 (90.8) | 291 (96.0) | 0.023 | 418 (93.9) | 191 (93.2) | 262 (92.3) | 0.429 | 382 (94.6) | 219 (94.8) | 270 (90.3) | 0.033 |
| Mucinous | 19 (5.5) | 13 (4.7) | 24 (7.8) | 22 (7.0) | 24 (7.6) | 10 (3.3) | 24 (5.4) | 14 (6.8) | 18 (6.3) | 19 (4.7) | 9 (3.9) | 28 (9.4) | ||||
| Others | 3 (0.9) | 3 (1.1) | 1 (0.3) | 0 (0.0) | 5 (1.6) | 2 (0.7) | 3 (0.7) | 0 (0.0) | 4 (1.4) | 3 (0.7) | 3 (1.3) | 1 (0.3) | ||||
| HISTOLOGICAL GRADE | ||||||||||||||||
| I/II | 317 (93.0) | 259 (94.9) | 285 (93.4) | 0.612 | 298 (95.8) | 282 (91.0) | 281 (94.3) | 0.040 | 404 (92.4) | 193 (95.1) | 264 (94.6) | 0.332 | 374 (94.4) | 214 (93.0) | 273 (93.2) | 0.713 |
| III/Undifferentiated | 24 (7.0) | 14 (5.1) | 20 (6.6) | 13 (4.2) | 28 (9.0) | 17 (5.7) | 33 (7.6) | 10 (4.9) | 15 (5.4) | 22 (5.6) | 16 (7.0) | 20 (6.8) | ||||
| LYMPHOVASCULAR INVASION | ||||||||||||||||
| No | 211 (64.7) | 186 (71.0) | 195 (69.9) | 0.209 | 212 (73.1) | 189 (64.5) | 191 (67.3) | 0.075 | 282 (67.8) | 127 (69.0) | 183 (68.5) | 0.951 | 258 (68.4) | 138 (64.8) | 196 (70.8) | 0.370 |
| Yes | 115 (35.3) | 76 (29.0) | 84 (30.1) | 78 (26.9) | 104 (35.5) | 93 (32.7) | 134 (32.2) | 57 (31.0) | 84 (31.5) | 119 (31.6) | 75 (35.2) | 81 (29.2) | ||||
| PERINEURAL INVASION | ||||||||||||||||
| No | 252 (84.8) | 208 (84.6 | 230 (87.1) | 0.657 | 235 (86.4) | 234 (84.5) | 221 (85.7) | 0.812 | 327 (85.8) | 152 (87.9) | 211 (83.4) | 0.425 | 299 (86.2) | 171 (83.4) | 220 (86.3) | 0.617 |
| Yes | 45 (15.2) | 38 (15.4) | 34 (12.9) | 37 (13.6) | 43 (15.5) | 37 (14.3) | 54 (14.2) | 21 (12.1) | 42 (16.6) | 48 (13.8) | 34 (16.6) | 35 (13.7) | ||||
| PRESENCE SYNCHRONOUS TUMORS | ||||||||||||||||
| No | 332 (95.7) | 260 (93.9) | 285 (91.9) | 0.135 | 288 (91.1) | 305 (96.8) | 284 (93.7) | 0.012 | 417 (93.7) | 196 (95.6) | 264 (93.0) | 0.469 | 381 (94.3) | 211 (91.3) | 285 (95.3) | 0.149 |
| Yes | 15 (4.3) | 17 (6.1) | 25 (8.1) | 28 (8.9) | 10 (3.2) | 19 (6.3) | 28 (6.3) | 9 (4.4) | 20 (7.0) | 23 (5.7) | 20 (8.7) | 14 (4.7) | ||||
| PRESENCE OF RECURRENCE | ||||||||||||||||
| No | 238 (68.6) | 188 (67.9) | 237 (76.5) | 0.034 | 232 (73.4) | 217 (68.9) | 214 (70.6) | 0.450 | 311 (69.9) | 144 (70.2) | 208 (73.2) | 0.602 | 286 (70.8) | 170 (73.6) | 207 (69.2) | 0.544 |
| Yes | 109 (31.4) | 89 (32.1) | 73 (23.5) | 84 (26.6) | 98 (31.1) | 89 (29.4) | 134 (30.1) | 61 (29.8) | 76 (26.8) | 118 (29.2) | 61 (26.4) | 92 (30.8) | ||||
Significant associations are indicated in bold.