Table 5.

Multivariate analysis of cancer-specific survival associated with different clinicopathological characteristics and treatment of patients with colorectal cancer.

Variables	Categories	Crude			Adjust 1*
		RR	IC 95%	p	RR	IC 95%	p
Gender	Male	1	–	–	1	–	–
	Female	0.77	0.61–0.97	0.031	0.73	0.57–0.93	0.011
Age at diagnose	<50	1	–	–	1	–	–
(in years)	≥50 to <75	1.16	0.90–1.50	0.240	1.22	0.93–1.61	0.140
	≥75	1.23	0.79–1.93	0.347	1.31	0.82–2.11	0.252
Clinical stage (AJCC)	0/I	1	–	–	1	–	–
	II	2.68	1.40–5.14	0.003	3.22	1.58–6.58	0.001
	III	4.89	2.50–9.57	<0.001	6.16	2.96–12.83	<0.001
	IV	11.46	5.99–21.91	<0.001	14.01	6.87–28.58	<0.001
Histological type	Adenocarcinoma	1	–	–	1	–	–
	Mucinous	0.58	0.33–1.04	0.070	0.53	0.28–1.00	0.051
	Others	1.13	0.33–3.82	0.840	1.04	0.30–3.61	0.947
Histological grade	I/II	1	–	–	1	–	–
	III/Undifferentiated	1.13	0.74–1.72	0.552	1.05	0.67–1.65	0.817
Lymphovascular	No	1	–	–	1	–	–
invasion	Yes	1.55	1.17–2.04	0.002	1.53	1.15–2.04	0.003
Perineural invasion	No	1	–	–	1	–	–
	Yes	1.17	0.88–1.56	0.264	1.12	0.83–1.51	0.454
Presence of recurrence	No	1	–	–	1	–	–
	Yes	3.49	2.74–4.45	<0.001	3.38	2.63–4.35	<0.001
Treatment period	2000–2009	1	–	–	1	–
	2010–2014	0.98	0.75–1.28	0.898	0.92	0.69–1.22	0.572
Surgery	No	1	–	–	1	–	–
	Yes	0.56	0.07–4.50	0.587	0.64	0.07–5.22	0.679
Adjuvant chemotherapy	No	1	–	–	1	–	–
	Yes	0.58	0.42–0.79	0.001	0.55	0.40–0.76	<0.001
Radiotherapy	No	1	–	–	1	–	–
	Yes, neoadjuvant	1.02	0.74–1.39	0.902	1.08	0.78–1.49	0.637
	Yes, adjuvant	0.76	0.33–1.75	0.526	0.72	0.29–1.80	0.487
	Yes, paliative	1.93	0.90–4.10	0.088	1.94	0.90–4.16	0.089

^*Adjust 1: Genetic ancestry components by AIM-INDEL panel.

NA, Not available.

Significant associations are indicated in bold.