Fig. 10.

Proteomics and phosphoproteomics analysis of N2a-APP695 cells exposed to fipronil sulfone (20) and dipropetryn. A) N2a-APP695 cells were exposed for 18 h to 20 μM fipronil sulfone (20), 100 μM dipropetryn or DMSO. This led to increased extracellular Aβ42 expression (3.58 ± 0.05 and 7.87 ± 0.81 fold change for fipronil sulfone (20) and dipropetryn, respectively, compared to DMSO-treated cells). Up/downregulated proteins in fipronil sulfone- (1634) and dipropetryn- (1638) treated cells versus DMSO-treated cells were identified and compared. Among the 261 common proteins, 178 proteins (listed in Supplementary Table 1) were either upregulated by both treatments or downregulated by both treatments. B) DAVID analysis of the 178 proteins common to fipronil sulfone (20) and dipropetryn treatments. Data are selected with p-value < 0.01 and FDR < 0.05. FDR, False Discovery Rate.