Fig. 11.
Short-term (72 hrs) time-course of fipronil (18) and fipronil sulfone (20) bioaccumulation in brain (A) and epididymal adipose tissue (B) following a single oral administration of fipronil (18) to mice. Fipronil (18) (10 mg/kg) was administrated by oral gavage at time 0. Animals were sacrificed at various times and plasma, epididymal adipose tissue and brain were collected. Fipronil (18) and fipronil sulfone (20) levels were quantified by LC-MS/MS. Concentrations are expressed as μg/brain or (μg/epididymal adipose tissue.