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. Author manuscript; available in PMC: 2020 Mar 11.
Published in final edited form as: J Alzheimers Dis. 2018;62(4):1663–1681. doi: 10.3233/JAD-170875

Fig. 7.

Fig. 7.

Pyrazoles trigger enhanced production of Aβ42 versus Aβ40 in neurons differentiated from human induced pluripotent stem cells. Neurons were derived from iPSCs obtained from healthy donor (APP WT, white bars) or from an AD patient with APP K724N mutation (grey bars). They were exposed for 24 h to DMSO (control), 100 μM aftin-5 or the nine pyrazoles. Cell supernatants were collected for extracellular Aβ40 and Aβ42 levels measurement by an ELISA assay. Levels are expressed as Aβ42/Aβ40 ratios ± SE of triplicate values. Horizontal dotted line indicates level for basal Aβ42/Aβ40 ratios.