| Methods |
RCT with randomisation sequence generated by computer code and allocation concealment achieved by sealed numbered envelopes opened sequentially. Blinding of participants and investigators (including outcome assessors) not reported. |
| Participants |
50 wounds in 47 patients (mean age: 19.6 years) with partial thickness burns (mean %TBSA: 6.3) less than 24 hours old. Chemical and electrical burns, grossly contaminated wounds, wounds more than 24 hours old and wounds treated with topical agents were excluded. |
| Interventions |
Biosynthetic dressing (Biobrane) versus twice‐daily application of SSD |
| Outcomes |
Time to complete wound healing
Level of pain
Need for surgery
Cost of dressing
Incidence of infection
Adverse events |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
"Computer generated codes" |
| Allocation concealment (selection bias) |
Low risk |
"Sealed numbered envelopes that were opened sequentially" |
| Blinding (performance bias and detection bias)
All outcomes |
High risk |
No blinding of participants, investigators or assessors |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Exclusions (n = 4 of 47) not likely to be related to outcomes |
| Selective reporting (reporting bias) |
Low risk |
All prespecified outcomes reported |
| Other bias |
Low risk |
50 wounds in 43 patients ‐ wounds randomised instead of patients, but unlikely to bias estimates |
