Grippaudo 2010.

Methods	Single centre, parallel, RCT
Participants	80 patients (male 31; female 49) aged between 2 and 65 years with second degree burns to TBSA < 10%.
Interventions	Topical application of ionic hydrogel (Procutase) versus application of silver sulphadiazine (SSD) 1% cream on emergency department presentation
Outcomes	Time to wound healing Wound infection Pain Adverse effects
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"..computer random number generator..." Comment: done
Allocation concealment (selection bias)	Unclear risk	"Once the patient was found to meet enrolment criteria (...) he or she was assigned to one arm or the other of the treatment tree". Inadequate information provided to ascertain whether allocation was concealed
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Participants would have been aware of treatment group assignment as interventions differed Treating study personnel would have been aware of treatment group assignment as interventions differed Outcome assessor was "unaware which treatment arm was assigned to the subject, and evaluated the wound after the removal of dressing and its cleaning with saline by the nurse"
Incomplete outcome data (attrition bias) All outcomes	Low risk	No losses to follow‐up
Selective reporting (reporting bias)	Unclear risk	Study protocol not available for assessment Key outcome data identified in study methods section disclosed Data on adverse events were not completely reported.
Other bias	Low risk	None detected