Guilbaud 1993.

Methods	RCT. Method of randomisation, allocation concealment and blinding of participants and investigators (including outcome assessors) not reported.
Participants	93 patients (mean age 35.7 years) with second‐degree burns admitted within 48 hours of injury. Mean %TBSA not described.
Interventions	Hydrogel dressing versus SSD, paraffin gauze or paraffin gauze with antibiotics or topical antibiotics
Outcomes	Time to complete wound healing Level of pain Number of dressing changes
Notes	Withdrawals I: 8/93 (9%) C: 8/93 (9%) Loss to follow‐up I: 8/93 (9%) C: 8/93 (9%)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomised allocation list
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding (performance bias and detection bias) All outcomes	High risk	Trial described as "open" with each participant acting as his own control. Investigator and patient not blinded (investigator chose the control treatment for individual patients)
Incomplete outcome data (attrition bias) All outcomes	High risk	Withdrawals from each subgroup as follows: (1) second‐degree burns 8/93 (9%); (2) donor sites 29/164 (18%); (3) meshed skin grafts 27/107 (25%); (4) loss of skin substance 20/96 (21%). The majority of withdrawals were from the experimental group, as proscribed in the protocol.
Selective reporting (reporting bias)	High risk	Adverse events not reported
Other bias	High risk	(1) Patients acted as own control, giving rise to potential unit of analysis errors; assessment of pain (one of the outcomes) thus not independent; (2) selection of control by investigators; (3) change of dressings at the discretion of the investigators; (4) selection of control sites in same patient made subjectively to ensure similarity with experimental site; (5) care protocols not identical: changes in dressings in experimental group led to withdrawal from the trial, but this was not required in the control group; (6) dressings supplied by company that manufactures them; no guarantees given that results safeguarded from company influence