2.
| Heavy compared to light sedation for opioid withdrawal | ||||||
|
Patient or population: patients with opioid withdrawal Settings: Intervention: Heavy Comparison: light sedation | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| light sedation | Heavy | |||||
| Participants experiencing adverse effects | Medium risk population | RR 3.21 (1.13 to 9.12) | 572 (2) | ⊕⊕⊕⊝ moderate1 | ||
| 13 per 1000 | 42 per 1000 (15 to 119) | |||||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; | ||||||
| GRADE Working Group grades of evidance High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 Less than 300 events