Table 1.
Characteristics of some liposomes proposed for liver macrophages targeting.
| Composition | Size/nm | Active | Effect | References |
|---|---|---|---|---|
| HSPC, CHOL, DSPG | 80 | Amphotericin B | Leishmanicide | (47) |
| DCP, DMPG, CHOL | 527.6 ± 58.2 | Vancomycin | Improvement of MRSA infection | (48, 49) |
| DPPC: PEG-(2000)-DSPE: NBD-PE:CHOL | 100 | Dexamethasone | Switch to M2 phenotype Liver injury and liver fibrosis reduction |
(50) |
| EPC:CHOL | 100–150 | Curcumin 1,25-dihydroxy-vitamin D3 (calcitriol) |
Switch to M2 phenotype Reduction in liver inflammation, fibrosis and fat accumulation |
(51) |
| DOPC: DOPE | 83.5–108.8 | Arginin-like ligands | Switch to M1 phenotype Antitumor |
(52) |
| DSPC: CHOL: Mannose | ~95 | Muramyl dipeptide (MDP) | Increase of Kupffer cells tumoricidal activity | (53) |
HSPC, hydrogenated soy phosphatidylcholine; CHOL, cholesterol; DSPG, distearoyl phosphatidylglycerol; DSPC, distearoyl 3 phosphatidylcholine; DCP, dicethylphosphate; DMPG, dimyristoylphoshatidylglycerol; DPPC, dipalmitoyl phosphatidylcholine; PEG-(2000)-DSPE, polyethyleneglycol-(2000)-distearoyl phosphatidylethanolamine; NBD-PE, N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine, triethyl-ammonium salt); EPC, egg phosphatidylcholine; DOPC, 1,2-dioleoyl-sn-glycero-3-phosphocholine; DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine.